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Anti-CCP
Lab code: CCP
 
Test Synonyms:
Anti-CCP; Anti-cyclic citrullinated peptide
 
Lab:
Immunology
Inpatient Req:
Core Lab (#84927)  
Outpatient Req:
Clinical Labs (#83608)  
Specimen:
Gold 5 ml
Result Time:
Performed once per week   Cost: $$
Reference Interval:
Negative <20 units (Normal); Weak Positive 20-39 units; Moderate Positive 40-59 units; Strong Positive >60 units;  
Important Information:
Anti-CCP antibody has about 80% sensitivity and about 90% specificity for Rheumatoid Arthritis (RA). In about 30% of rheumatoid factor (RF) negative RA (seronegative RA) anti-CCP antibody is present. Testing for the combination of anti-CCP antibodies and IgM RF may be better for excluding the diagnosis of RA than is achievable by testing for either antibody alone. High titers are seen in erosive and progressive disease.