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Liver biopsy
Test Synonyms:
Liver biopsy
Anatomic Pathology
Inpatient Req:
Pathology (#10016)  
Outpatient Req:
Pathology (#10016)  
Result Time:
3 days for routine studies  
Reference Interval:
Important Information:
Biopsies for routine processing are submitted in 10% formalin in the regular manner. When demonstration of fat is required (e.g., for suspected Reye’s Syndrome) the biopsy should be kept unfixed in saline or on a saline-moistened sponge and submitted to the Pathology Chief Resident or, after 5:00pm or on holidays and weekends, to the Pathology Resident on-call (x6-2967 or through page x6-2241). If submitted in formalin, fat stains can be performed, though less successfully.

NOTE: Pathology requisition slips should include relevant clinical information and diagnostic considerations.

If glycogen storage disease or other storage diseases are suspected, one portion of the biopsy should be placed in absolute alcohol, one small portion prepared for electron microscopic evaluation, one portion frozen in dry ice for enzymatic analysis and the rest fixed in formalin. Dry ice can be obtained in the Warren 5 Immunopathology Laboratory. Alcohol is obtainable from the Blake 3 Pathology Laboratory (x4-1425). If electron microscopy or immunofluorescence examination is desirable, portions of the specimen should be sampled and handled as appropriate (see “Electron Microscopy” and “Biopsy for Immunofluorescence”). NOTE: For these types of unusual diagnoses for which special studies are required, contacting gastrointestinal pathology staff is recommended prior to the procedure.

Minimum time for routine diagnosis is 24 hours. For special studies, time is variable according to study performed.

Last Reviewed on 4/22/2005