<%@LANGUAGE="VBSCRIPT" CODEPAGE="1252"%> MGH Laboratory Handbook - Lab Update
  Estimated Glomerular Filtration Rate      



Beginning 2/12/2008 the MGH Core Chemistry laboratory and the Yawkey laboratory will report the estimated Glomerular Filtration Rate (eGFR) for all adults that have plasma or serum creatinine testing performed. The eGFR is based on the creatinine level, age, and gender.  The calculation is based on the abbreviated MDRD and use of this equation for estimation of GFR is recommended both by the National Kidney Foundation and the National Kidney Disease Education Program (NKDEP).  The eGFR will be reported only for adults (over age 18 years). In African American patients the result should be multiplied by a factor of 1.21.

The MDRD equation has not been validated for use in the elderly (> 70 years of age), pregnant women, patients with serious co-morbid conditions, or persons with extremes of body size or muscle mass (e.g., obese, severely malnourished, amputees, paraplegics or other muscle-wasting diseases). Application of the equation to these patient groups may lead to errors in GFR estimation.  The eGFR should be also be interpreted cautiously in the patients with acute kidney failure, dialysis dependant patients, patients reporting exceptional dietary intake (e.g. vegetarian diet, high protein diets, creatine supplementation), and patients with severe liver disease.

In addition, in order to support this calculation, all plasma and serum creatinine levels will now be reported with an additional significant figure, e.g. 1.23 mg/dL not 1.2 mg/dL.

The eGFR is calculated by the abbreviated MDRD equation : GFR (mL/min/1.73 m2) = 175 x (Scr)^-1.154 x (Age)^-0.203 x (0.742 if female) x (1.210 if African American)

More information regarding the eGFR and its use can be found at the following links:

NKDEP Rationale for Use and Reporting of eGFR

National Kidney Foundation Information on Use of the eGFR


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This page last updated on February 1, 2013