From: Elizabeth M. Van Cott, M.D., and Michael Laposata, M.D., Ph.D., “Coagulation.” In: Jacobs DS et al, ed. The Laboratory Test Handbook, 5th Edition. Lexi-Comp, Cleveland, 2001; 327-358.

Related Information

Activated Protein C Resistance and the Factor V Leiden Mutation
Coagulation Factor Assays

Abstract See Activated Protein C Resistance and Factor V Leiden Mutation. The term “factor V Leiden” is often used interchangeably with activated protein C resistance, although they are not true synonyms. The factor V Leiden mutation causes the vast majority of cases of activated protein C resistance. Whether or not additional mutations other than factor V Leiden can cause clinically-significant activated protein C resistance is under continued investigation.